DISTINCT HISTOPATHOLOGICAL PHENOTYPES OF SEVERE ALCOHOLIC HEPATITIS SUGGEST DIFFERENT MECHANISMS DRIVING LIVER INJURY AND FAILURE

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH) pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH remains obscure.This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH pathogenesis.Immunohistochemistry anal

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Development of a Digital Health Intervention for Rheumatoid Arthritis Symptom Management in a Biotechnology Industry Context: Protocol for the Application of a Human-Centered Design Framework

BackgroundInvolving chronically ill patients in the management of their health is widely recognized as a vital component of high-quality health care.However, to assume the role of informed participants, patients need both access to their health information and assistance in interpreting such data.Smartphone technology with SMS text messaging functi

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Effects of metformin on body weight in patients with type 2 diabetes mellitus,receiving insulin analogue treatment

Aims.To study the dynamics of body weight, waist circumference, blood lipid and insulin demand in patients with type 2 diabetes mellitus (T2DM) during first year of combined treatment with metformin and insulin analogues, compared with insulin analogue monotherapy.Materials and Methods.We examined 78 patients with T2DM on newly initiated insulin th

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